Reactions of the readily accessible electrophile, trifluoroacetyl triflate: a very reactive agent for trifluoroacetylations at oxygen, nitrogen, carbon, or halogen centers

TR Forbus Jr, SL Taylor, JC Martin

Index: Forbus, T. R.; Taylor, S. L.; Martin, J. C. Journal of Organic Chemistry, 1987 , vol. 52, # 19 p. 4156 - 4159

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Citation Number: 37

Abstract

Conclusion We have found that TFMT is conveniently and economically prepared in high yield by the reaction of Tf20 with strong Lewis acids such as TfOSbF4, which is formed in the reaction of Tf20 with SbF5. Although TFMT is readily accessible as a result of this reaction, we have found no examples of trifluoromethylation by this reagent, contrary to published reports. 4b Initial reaction with a wide range of nucleophiles occurs at sulfur to displace ...