Chemical Communications 2012-11-04

Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities.

Sajesh P Thomas, K Nagarajan, T N Guru Row

Index: Chem. Commun. (Camb.) 48(85) , 10559-61, (2012)

Full Text: HTML

Abstract

Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employed to detect the presence of a polymorphic impurity in a mixture of polymorphs.

Related Compounds

Related Articles:

Pharmacophoric features of drugs with guanylurea moiety: an electronic structure analysis.

2013-04-01

[J. Mol. Model. 19(4) , 1865-74, (2013)]

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.

2015-08-05

[J. Neurosci. 35 , 11125-32, (2015)]

Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.

2015-07-01

[Bioorg. Med. Chem. 23 , 3040-58, (2015)]

mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties.

2014-04-01

[J. Pharmacol. Exp. Ther. 349(1) , 155-64, (2014)]

A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.

2015-11-01

[Pain 156 , 2364-72, (2015)]

More Articles...