Synthesis of farnesol isomers via a modified Wittig procedure.
José S Yu, Troy S Kleckley, David F Wiemer
Index: Org. Lett. 7 , 4803-4806, (2005)
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Abstract
[structure: see text] The four olefin stereoisomers of farnesol have been synthesized from readily available nerylacetone or commercial geranylacetone. A new variation on the use of beta-oxido ylides favored the (2Z)-stereoisomers, whereas the (2E)-isomers were obtained through a classical Horner-Wadsworth-Emmons condensation with triethyl phosphonoacetate and reduction of the resulting ester.
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