EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion.

H Okano, A Inui, N Ueno, S Morimoto, A Ohmoto, M Miyamoto, N Aoyama, Y Nakajima, S Baba, M Kasuga, Hiroyuki Okano, Akio Inui, Naohiko Ueno, Shinsuke Morimoto, Akiyoshi Ohmoto, Masaki Miyamoto, Nobuo Aoyama, Yoshito Nakajima, Shigeaki Baba, Masato Kasuga

Index: Peptides 17(6) , 895-900, (1996)

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Abstract

We investigated the efficacy and the mechanism of action of EM523L, a nonpeptide motilin agonist (motilide), on the stimulation of gastric emptying and on the release of gut peptides after ingestion of a solid meat in normal controls (n = 8) and in diabetic patients (n = 8) with signs of neuropathy. A dose of 2 mg EM523L was administered IV over 15 min just after ingestion of a solid meal (200 kcal Gastric emptying was measured by a radionuclide technique. EM523L accelerated gastric emptying and markedly augmented postprandial pancreatic polypeptide (PP) response in both normal control and diabetic patients. This may suggest the mediation of the Vagal-cholinergic pathway to accelerate gastric emptying. The present study offers a promising therapeutic potential of the motilide in gastrointestinal motility disorders like those observed in diabetics mellitus.