Tetrahedron letters

Iodine catalyzed conjugate addition of mercaptans to α, β-unsaturated carboxylic acids under solvent-free condition

S Gao, T Tzeng, MNV Sastry, CM Chu, JT Liu, C Lin…

Index: Gao, Shijay; Tzeng, Tingkai; Sastry; Chu, Cheng-Ming; Liu, Ju-Tsung; Lin, Chunchi; Yao, Ching-Fa Tetrahedron Letters, 2006 , vol. 47, # 12 p. 1889 - 1893

Full Text: HTML

Citation Number: 54

Abstract

We have described herein molecular iodine catalyzed Michael addition of thiol to α, β- unsaturated carboxylic acids. This environmentally benign catalytic system (iodine) used under mild and solvent-free conditions to achieve the corresponding adducts in excellent yield.

Related Articles:

Fluoride ion-catalyzed conjugate addition for easy synthesis of 3-sulfanylpropionic acid from thiol and α, β-unsaturated carboxylic acid

[Gao, Shijay; Tseng, Chi; Tsai, Cheng Hsuan; Yao, Ching-Fa Tetrahedron, 2008 , vol. 64, # 8 p. 1955 - 1961]

Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L

[Song, Jiangli; Jones, Lindsay M.; Kumar, G. D. Kishore; Conner, Elizabeth S.; Bayeh, Liela; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Chen, Shen-En; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G. ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 6 p. 450 - 453]

Conformational analysis and photochemical behavior of sulfoxides in the naphtho [1, 2-b] thiopyran and naphtho [2, 1-b] thiopyran series

[Still, Ian W. J.; Arora, Parkash C.; Hasan, S. Khaquan; Kutney, Gerald W.; Lo, LAwrence Y. T.; Turnbull, Kenneth Canadian Journal of Chemistry, 1981 , vol. 59, p. 199 - 209]

Syntheses in the Thiochromanone Field1

[Tarbell et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 1985]

More Articles...