ACS Chemical Biology 2012-01-20

Novel modifications in RNA.

Kelly Phelps, Alexi Morris, Peter A Beal

Index: ACS Chem. Biol. 7(1) , 100-9, (2012)

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Abstract

The past several years have seen numerous reports of new chemical modifications for use in RNA. In addition, in that time period, we have seen the discovery of several previously unknown naturally occurring modifications that impart novel properties on the parent RNAs. In this review, we describe recent discoveries in these areas with a focus on RNA modifications that introduce spectroscopic tags, reactive handles, or new recognition properties.

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