Ligand effects on the stereochemical outcome of Suzuki-Miyaura couplings.

Guo-Ping Lu, Karl R Voigtritter, Chun Cai, Bruce H Lipshutz

Index: J. Org. Chem. 8th ed., 77 , 3700-3703, (2012)

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Abstract

The ligands associated with various Pd catalysts play a crucial role in determining the stereochemistry of cross-couplings between boronic acids and Z-alkenyl halides. A ligand on palladium has been found that leads to the desired products under mild conditions and in high yields that, in most cases, retain their Z-olefin geometry.© 2012 American Chemical Society