5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.
Mikhail V Skorobogatyi, Alexei V Ustinov, Irina A Stepanova, Anna A Pchelintseva, Anna L Petrunina, Valeriya L Andronova, Georgi A Galegov, Andrei D Malakhov, Vladimir A Korshun
Index: Org. Biomol. Chem. 4(6) , 1091-6, (2006)
Full Text: HTML
Abstract
Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.
Related Compounds
Related Articles:
Discovery of novel SERCA inhibitors by virtual screening of a large compound library.
2011-05-01
[Eur. J. Med. Chem. 46 , 1512-23, (2011)]
2008-01-01
[Chemistry 14(32) , 10012-28, (2008)]
5-Alkynyl-2'-deoxyuridines, containing bulky aryl groups: evaluation of structure-anti-HSV-1 activity relationship. Skorobogatyi MV, et al.
1. Skorobogatyi MV, et al.
[Tetrahedron 62(6) , 1279-1287, (2006)]