Advances in the Carbonylation of Aryl Halides Using Palladium Catalysts
M Beller, AF Indolese
Index: Beller, Matthias; Indolese, Adriano F. Chimia, 2001 , vol. 55, # 9 p. 684 - 687
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Citation Number: 26
Abstract
Elegant work by researchers from Hoffmann-La Roche also demonstrated the industrial applicability of such a reac- tion in the commercial process for Lazabemide, a monamine oxidase B in- hibitor. In this process the aminocar- bonylation of the commercially available 2,5-dichloropyridine with ethylenedi- amine is performed with a Pd/dppp cata- lyst with comparably high catalyst pro- ductivity (Scheme 3). Due to the enhanced reactivity of the 2-position compared to ...
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