Bioorganic & Medicinal Chemistry Letters 2001-12-17

Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.

S Padmanabhan, R C Lavin, P M Thakker, J Guo, L Zhang, D Moore, M E Perlman, C Kirk, D Daly, K J Burke-Howie, T Wolcott, S Chari, D Berlove, J B Fischer, W F Holt, G J Durant, R N McBurney

Index: Bioorg. Med. Chem. Lett. 11(24) , 3151-5, (2001)

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Abstract

Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.

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