Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase fromToxoplasma gondii

Miryam Andrea Hortua Triana, My-Hang Huynh, Manuel F. Garavito, Barbara A. Fox, David J. Bzik, Vern B. Carruthers, Monika Löffler, Barbara H. Zimmermann, Miryam Andrea Hortua Triana, My-Hang Huynh, Manuel F Garavito, Barbara A Fox, David J Bzik, Vern B Carruthers, Monika Löffler, Barbara H Zimmermann

Index: Mol. Biochem. Parasitol. 184(2) , 71-81, (2012)

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Abstract

Graphical abstract Toxoplasma gondii dihydroorotate dehydrogenase is an essential mitochondrial enzyme that exhibits inhibitor sensitivities distinct from those of the human and Plasmodium falciparum enzymes.