Asymmetric Hydrogenation of Dehydrodipeptides with Rhodium (I)–Chiral Diphosphinites. Selective (S, S)-and (R, R)-Product Formation by Double Asymmetric …

M Yatagai, T Yamagishi, M Hida

Index: Yatagai; Yamagishi; Hida Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 3 p. 823 - 826

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Citation Number: 18

Abstract

In the hydrogenation of dehydrodipeptides, the effect of chiral center of the substrate ((S) or (R)) on the asymmetric induction was examined using the catalysts of Rh (I)–chiral diphosphinite containing pyrrolidine moiety (POP). The catalysts with POP's having the ω- (dimethylamino) alkyl group indicated an extremely large double asymmetric induction to give (S, S)-or (R, R)-product in high stereoselectivities, depending on the chiral center of ...