A method for the selective protection of aromatic amines in the presence of aliphatic amines

…, S Abbott, N Moreau, D Lee, C Penney, B Zacharie

Index: Perron, Valerie; Abbott, Shaun; Moreau, Nancie; Lee, Devin; Penney, Christopher; Zacharie, Boulos Synthesis, 2009 , # 2 p. 283 - 289

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Citation Number: 11

Abstract

Abstract A simple and efficient procedure has been developed for the regioselective protection of aromatic amines in the presence of aliphatic amines. The method is general for the preparation of mono-N-Boc,-N-Cbz,-N-Fmoc or-N-Alloc aromatic amines in high yield without affecting the aliphatic amines. This approach is applicable to substituted (aminoalkyl) aniline compounds with different functionalities and was employed to supply ...