Pradeep Kumar Gupta, Shiv Kumar Yadav, Yangchen Doma Bhutia, Poonam Singh, Pooja Rao, Niranjan Laxman
KG Gujar
Index: Gupta, Pradeep Kumar; Yadav, Shiv Kumar; Bhutia, Yangchen Doma; Singh, Poonam; Rao, Pooja; Gujar, Niranjan Laxman; Ganesan, Kumaran; Bhattacharya, Rahul Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3888 - 3896
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Abstract
Abstract Fentanyl [N-(1-phenethyl-4-piperidinyl) propionanilide] is a popular narcotic analgesic agent that is clinically used worldwide. However, fentanyl and its several analogs have caused abuse and fatalities in humans due to overdosing and narrow therapeutic index. The present study reports the synthesis and comparative bioefficacy of fentanyl and its four analogs, viz., N-(1-propyl-4-piperidinyl) propionanilide (1), N-(1-(2-phenoxyethyl)-4 ...
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