New polycyclic pyrimidine derivatives with antiplatelet in vitro activity: Synthesis and pharmacological screening

…, A Ranise, F Bondavalli, E Barocelli, V Ballabeni…

Index: Bruno, Olga; Schenone, Silvia; Ranise, Angelo; Bondavalli, Francesco; Barocelli, Elisabetta; Ballabeni, Vigilio; Chiavarini, Milena; Bertoni, Simona; Tognolini, Massimiliano; Impicciatore, Mariannina Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 629 - 636

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Citation Number: 48

Abstract

The preparation and the pharmacological screening of novel anti-aggregatory/antiphlogistic polycyclic pyrimidine derivatives are described. The compounds were developed starting from bioactive 2-aminobenzopyranopyrimidine derivatives in order to assess the importance of the benzopyrano [4, 3-d] pyrimidine structure and the role of an amino basic moiety in position 2. Antiplatelet activity was assessed in vitro against ADP and arachidonic acid- ...