Synthesis of 2-imidazolidinylidene propanedinitrile derivatives as stimulators of gastrointestinal motility. 1
S Sasho, H Obase, S Ichikawa, T Kitazawa…
Index: Sasho; Obase; Ichikawa; Kitazawa; Nonaka; Yoshizaki; Ishii; Shuto Journal of Medicinal Chemistry, 1993 , vol. 36, # 5 p. 572 - 579
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Citation Number: 34
Abstract
Alterations in the motility of the alimentary canal are associated with many symptoms of gastrointestinal disease. Examples of the digestive diseases that are manifested by a disturbance in motor activity are dysphagia, gastric stasis, vomiting, abdominal pain, paralytic ileus, and constipation. A number of gastrointestinalmotility enhancing agenta, such as metoclopramide (3), neostigmine (41, and bethanechol, have been developed to ...
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