Chemically-enabled synthesis of 1, 2, 3, 4-tetrahydroisoquinolin-1-ones

…, EL Conn, KJ Dirico, Y Hui, RM Oliver, JA Southers…

Index: Humphries, Paul S.; Balan, Gayatri; Bechle, Bruce M.; Conn, Edward L.; Dirico, Kenneth J.; Hui, Yu; Oliver, Robert M.; Southers, James A.; Yang, Xiaojing Tetrahedron Letters, 2009 , vol. 50, # 18 p. 2140 - 2143

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Citation Number: 5

Abstract

We have developed a number of efficient protocols for the facile synthesis of 1, 2, 3, 4- tetrahydroisoquinolin-1-ones. This synthetic methodology allowed concise and efficient exploration of the SAR in all areas of the molecule. A number of these methods proved to be versatile, efficient and amenable to parallel synthesis.