Farmaco

1-Aryl-1H-pyrazole-5-acetic acids with antiinflammatory, analgesic and other activities

G Menozzi, L Mosti, P Schenone, M D'Amico…

Index: Mosti; Menozzi; Schenone; D'Amico; Falciani; Rossi Farmaco, 1994 , vol. 49, # 1 p. 45 - 50

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Citation Number: 22

Abstract

Summary—Reaction of methyl 4-methoxy-2-dimethylaminomethylene-3-oxobutanoate with arylhydrazines gave methyl l-aryl-5-(methoxymethyl)-1H-pyrazole-4-carboxylates 1 in high yields. Esters 1 were hydrolyzed to the relative carboxylic acids, which were converted by heating to 1-aryl-5-(methoxymethyl)-1H-pyrazoles 3 in good yields. Reaction of 3 with hydrobromic acid afforded the intermediate l—aryl—S-(bromomethyl)-lH-A pyrazoles, ...