Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7 H-[1, 4] Oxazino [3, 2-g] quinolin-7-ones

RI Higuchi, KL Arienti, FJ López, NS Mani…

Index: Higuchi, Robert I.; Arienti, Kristen L.; Lopez, Francisco J.; Mani, Neelakhanda S.; Mais, Dale E.; Caferro, Thomas R.; Long, Yun Oliver; Jones, Todd K.; Edwards, James P.; Zhi, Lin; Schrader, William T.; Negro-Vilar, Andres; Marschke, Keith B. Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2486 - 2496

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Citation Number: 38

Abstract

Recent interest in orally available androgens has fueled the search for new androgens for use in hormone replacement therapy and as anabolic agents. In pursuit of this, we have discovered a series of novel androgen receptor modulators derived from 7 H-[1, 4] oxazino [3, 2-g] quinolin-7-ones. These compounds were synthesized and evaluated in competitive binding assays and an androgen receptor transcriptional activation assay. A number of ...