Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists

T Hoffmann, M Bös, H Stadler, P Schnider…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365

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Citation Number: 23

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 6 Moreover this structural class, which displays simple achiral features, had previously not been described in the patent literature either as an NK 1 lead structure or as a pharmaceutically active chemical class per se. ...