Tetrahedron Letters

Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines

C Nitsche, CD Klein

Index: Nitsche, Christoph; Klein, Christian D. Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5197 - 5201

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Citation Number: 14

Abstract

Two aqueous, one-pot, microwave-assisted methods for the rapid synthesis of N-substituted rhodanines from amine substrates are described. Alkyl-and benzylamines could be converted into the corresponding rhodanines with an atom-efficient one-pot, three-step protocol based on carbon disulfide and chloroacetic acid in short reaction times and good to excellent yields. An alternative, microwave-assisted one-pot, one-step protocol using bis ( ...