Polyvinylalcohol substituted with triethyleneglycolmonoethylether as a new material for preparation of solid dispersions of hydrophobic drugs.

Isabella Orienti, Federica Bigucci, Barbara Luppi, Teresa Cerchiara, Guendalina Zuccari, Paolo Giunchedi, Vittorio Zecchi

Index: Eur. J. Pharm. Biopharm. 54(2) , 229-33, (2002)

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Abstract

Among the different methods used to increase the aqueous drug solubility, the preparation of a solid dispersion with a soluble carrier represents an interesting formulative approach. We substituted polyvinylalcohol with triethyleneglycolmonoethylether and obtained a suitable material for the formulation of a solid dispersion of progesterone, by spray-drying. In particular, we evaluated the influence of the polyvinylalcohol substitution degree and the polymer-drug weight ratios in the preparative mixture on the progesterone dissolution rate in the aqueous environment.