A new expedient route to 2, 6??diaryl??3??cyano??4??(trifluoromethyl) pyridines

Y Yamaguchi, I Katsuyama, K Funabiki…

Index: Yamaguchi; Katsuyama; Funabiki; Matsui; Shibata Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 4 p. 805 - 810

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Citation Number: 23

Abstract

Abstract 1-Aryl-4, 4, 4-trifluoro-1, 3-butanediones 1 react with β-amino-β-arylacrylonitrile 2, readily available from acetonitrile with aryl nitriles in the presence of potassium t-butoxide, to afford the corresponding 2, 6-diaryl-3-cyano-4-(trifluoromethyl) pyridines 3 in moderate to excellent yields.