Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity
KC Nicolaou, AF Stepan, T Lister, A Li…
Index: Nicolaou, K. C.; Stepan, Antonia F.; Lister, Troy; Li, Ang; Montero, Ana; et al. Journal of the American Chemical Society, 2008 , vol. 130, p. 13110 - 13119
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Citation Number: 89
Abstract
The molecular design, chemical synthesis, and biological evaluation of two distinct series of platensimycin analogues with varying degrees of complexity are described. The first series of compounds probes the biological importance of the benzoic acid subunit of the molecule, while the second series explores the tetracyclic cage domain. The biological data obtained reveal that, while the substituted benzoic acid domain of platensimycin is a highly ...
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