Erythema multiforme-like contact reaction due to liquid-formulated 2,2-dibromo-3-nitrilopropionamide: involvement of cytotoxic T-lymphocyte reaction.
A Senoh, Y Tokuyama, Y Nakayama, K Fujii, K Iwatsuki
Index: Clin. Exp. Dermatol. 34(8) , e732-6, (2009)
Full Text: HTML
Abstract
Erythema multiforme (EM)-like contact reactions are induced by exposure to various chemicals. We report two industrial workers from a paper mill who presented with generalized EM-like lesions 17 and 10 days, respectively, after accidental exposure to liquid-formulated 2,2-dibromo-3-nitrilopropionamide (DBNPA) 20%. The EM-like lesions appeared as subepidermal blisters associated with many necrotic or apoptotic keratinocytes and dense lymphocytic infiltration in the epidermis. Most of the infiltrating cells in the epidermis were CD8-positive T lymphocytes expressing cytotoxic molecules, including T cell-restricted intracellular antigen (TIA)-1, granzyme B and granulysin. Steroid pulse therapy failed to suppress the development of the lesions sufficiently, but cyclosporin 2.5-3 mg/kg successfully controlled the disease. DBNPA-induced, generalized EM-like eruptions may be mediated by cytotoxic T-lymphocytes.
Related Compounds
Related Articles:
2004-02-01
[Environ. Toxicol. Chem. 23(2) , 339-47, (2004)]
Laboratory studies of disinfectants against Legionella pneumophila.
1980-10-01
[Appl. Environ. Microbiol. 40(4) , 697-700, (1980)]
The chronic aquatic toxicity of a microbicide dibromonitrilopropionamide.
2012-03-01
[Toxicol. Ind. Health 28(2) , 181-5, (2012)]
Synthesis of 2, 2-dibromo-2-cyanoacetamide by in situ oxidation bromination. LI WX and LI FG.
[Fine and Specialty Chemicals 11 , 018, (2012)]
Molecular Structure and Internal Rotation Barrier of Dibromocyanoacetamide. Wang YF, et al.
[Chem. Res. Chin. Univ. 3 , 034, (1992)]