The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis.

H Uzun, S Tuzun, N Ozaras, S Aydin, R Ozaras, S Dondurmaci, F Tuzun

Index: Acta Orthop. Scand. 72(5) , 499-502, (2001)

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Abstract

39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 x 100 mg), tiaprofenic acid (n 14, 2 x 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF-alpha levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.