Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization

H Xie, L Zeng, S Zeng, X Lu, G Zhang, X Zhao…

Index: European Journal of Medicinal Chemistry, , vol. 52, p. 205 - 212

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Citation Number: 21

Abstract

... European Journal of Medicinal Chemistry. ... HCl, rt; (g) POCl 3 , DIEA, toluene, 70–80 °C; (h) NaH, MeI, THF, rt; (i) 1N NaOH/H 2 O, 80 °C; (j) (Boc) 2 O, DMAP, Et 3 N, THF, rt; (k) 2-(bromomethyl) benzonitrile, NaH, LiBr, DME/DMF, 65 °C; (l) 3-(R)-aminopiperidine, NaHCO 3 ...