Organic letters

Regio-and chemoselective multiple functionalization of pyrimidine derivatives by selective magnesiations using TMPMgCl· LiCl

M Mosrin, P Knochel

Index: Mosrin, Marc; Knochel, Paul Organic Letters, 2008 , vol. 10, # 12 p. 2497 - 2500

Full Text: HTML

Citation Number: 104

Abstract

Successive regio-and chemoselective magnesiations of pyrimidines using TMPMgCl· LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported.