[Effect of L-lysine-a-oxidase on reproduction of herpes simplex type I virus in vitro].

I P Smirnova, S V Diorditsa, S B Alekseev, I Z Zaĭtsev

Index: Vopr. Med. Khim. 44(4) , 384-7, (1998)

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Abstract

L-lysin-a-oxidase (LO), a fungal enzyme catalysing oxidative deamination of L-lysin, was used for the inhibition of the reproduction of herpes simplex virus type 1 (HSV-1). Antiviral activity of LO was tested in vitro. The expression of viral antigens and CPE of HSV-1 was inhibited by LO at a concentration 0.7 mg/ml.