Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.

H Ohashi, A Ueno, T Nakao, J Ito, K Kimura, M Ishikawa, H Kawai, H Iijima, T Osawa

Index: Bioorg. Med. Chem. Lett. 9(14) , 1945-8, (1999)

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Abstract

Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.