Methylation of lithioisobutyrophenone in weakly polar aprotic solvents. The effect of aggregation

LM Jackman, BC Lange

Index: Jackman,L.M.; Lange,B.C. Journal of the American Chemical Society, 1981 , vol. 103, p. 4494

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Citation Number: 95

Abstract

Abstract: The ratios (C/O) of C-and 0-methylation of lithioisobutyrophenone in dioxolane and in dimethoxyethane have been determined over a wide temperature range and in the presence and absence of LiCl. Comparison of these results with those of earlier NMR studies has established that ion-pair aggregates are the true reactants. The effects of crown ethers,[2.1. l] cryptand, and hexamethylphosphoric triamide on both C/O and chemical ...