Journal of Antibiotics 1986-08-01

K-252a, a potent inhibitor of protein kinase C from microbial origin.

H Kase, K Iwahashi, Y Matsuda

Index: J. Antibiot. 39 , 1059, (1986)

Full Text: HTML

Abstract

K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.

Related Compounds

Related Articles:

Rat BMSCs initiate retinal endogenous repair through NGF/TrkA signaling.

2015-03-01

[Exp. Eye Res. 132 , 34-47, (2015)]

HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells.

2014-11-01

[J. Virol. 88(22) , 13482-94, (2014)]

Dopamine-sensitive signaling mediators modulate psychostimulant-induced ultrasonic vocalization behavior in rats.

2016-01-01

[Behav. Brain Res. 296 , 1-6, (2015)]

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

2007-12-18

[Proc. Natl. Acad. Sci. U. S. A. 104 , 20523-8, (2007)]

K-252a, a novel microbial product, inhibits smooth muscle myosin light chain kinase.

1988-05-05

[J. Biol. Chem. 263 , 6215-6219, (1988)]

More Articles...