Chemical Communications

Regioselective N-alkylation of 2-aminobenzothiazoles with benzylic alcohols

F Li, H Shan, Q Kang, L Chen

Index: Li, Feng; Shan, Haixia; Kang, Qikai; Chen, Lin Chemical Communications, 2011 , vol. 47, # 17 p. 5058 - 5060

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Citation Number: 34

Abstract

The N-alkylation of amines is one of the most fundamental and important C–N bond-forming transformations in organic synthesis. 1 Traditionally, the N-alkylation of amines was performed with alkyl halides using stoichiometric bases. Recently, much attention has been paid to the N-alkylation of amines with alcohols as alkylating agents based on transition metal-catalyzed “hydrogen autotransfer (or hydrogen-borrowing) process”. 2 Such methods are ...

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