Selective Oxidation of Acetophenones Bearing Various Functional Groups to Benzoic Acid Derivatives with Molecular Oxygen

R Nakamura, Y Obora, Y Ishii

Index: Nakamura, Ryota; Obora, Yasushi; Ishii, Yasutaka Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1677 - 1684

Full Text: HTML

Citation Number: 18

Abstract

Abstract Acetophenones substituted by alkyl, alkoxy, acetoxy, and halogen groups were selectively oxidized with molecular oxygen to the corresponding benzoic acids by using the N, N′, N′′-trihydroxyisocyanuric acid (THICA)/cobalt (II) acetate [Co (OAc) 2] and THICA/Co (OAc) 2/manganese (II) acetate [Mn (OAc) 2]. For example, 4- methylacetophenone was selectively oxidized with molecular oxygen to 4-acetylbenzoic ...