Tetrahedron

An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from dysoxylum binectariferum: isolation, structure and total synthesis

…, SL Kattige, SV Bhat, B Alreja, NJ De Souza, RH Rupp

Index: Naik, Ramachandra G.; Kattige, S. L.; Bhat, S. V.; Alreja, B.; Souza, N. J. de; Rupp, R. H. Tetrahedron, 1988 , vol. 44, # 7 p. 2081 - 2086

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Citation Number: 134

Abstract

(+)-cis-5, 7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-methyl) piperidinyl]-4H-1-benzopyran-4- one was identified as the antiinflammatory cum immunomodulatory principle of the stem bark of Dysoxylum binectariferum. The sequence devised for its total synthesis was also used to synthesise its (-)-enantiomer and the racemate.