Tris acetylacetonate aluminium(III) induces osmotic fragility and acanthocyte formation in suspended erythrocytes

Paolo Zatta, Maurizio Perazzolo, Benedetto Corain, P Zatta, M Perazzolo, B Corain

Index: Toxicol. Lett. 45(1) , 15-21, (1989)

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Abstract

Tris acetylacetonate aluminium(III) (Al(acac) 3), dissolved in water, is effective in producing osmotic fragility in suspended erythrocytes in the concentration range of 0.034–0.34 mmol/l. Water solutions of Tris maltolate aluminium(III) (Al(malt) 3) and aluminium lactate (Al(lac) 3) are also effective but the dose-response behavior is less pronounced. Moreover, only Al(acac) 3 induces a prominent generation of acanthocytes. The stronger effects of Al(acac) 3 on membrane stability are attributed to the greater solubility of this complex in the cell membrane.