Substituted benzyloxyarylacetic acids: synthesis and quantitative relationships between structure and antiinflammatory activity

M Kuchař, B Brůnová, V Rejholec…

Index: Kuchar; Brunova; Rejholec; et al. Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 5 p. 1723 - 1735

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Citation Number: 28

Abstract

With all the acids VI-IX, antiinflammatory activity was examined in two tests, viz. by inhibition of kaolin edema 12 and by inhibition of Freund's adjuvant edema 13. In both tests the effect was expressed by an activity index. This index IK or IF was calculated as a ratio of the effect of the tested compound to that of the standard in a given experimental edema. The standard used was 3-chloro-4-allyloxyphenylacetic acid (Mervan) lO. 14. The experimental results ...