Total synthesis of maytansine

EJ Corey, LO Weigel, AR Chamberlin…

Index: Corey; Weigel; Chamberlin; et al. Journal of the American Chemical Society, 1980 , vol. 102, # 21 p. 6613 - 6615

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Citation Number: 103

Abstract

1 widespread interest in chemical synthesis. 2 We now report the first total synthesis of this important substance which has been used in clinical studies with some success in the treatment of acute lymphoblastic leukemia and malignant lymph~ ma.~ The synthesis outlined herein, which procedes with uniformly good yields in the individual steps and with excellent stereochemical control, represents the denouement of the plan which earlier led ...