European journal of medicinal chemistry

Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives

KY Lee, KS Lee, C Jin, YS Lee

Index: Lee, Ki Yong; Seob Lee, Kwang; Jin, Changbae; Lee, Yong Sup European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1331 - 1334

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Citation Number: 5

Abstract

Excessive calpain activation contributes to serious cellular damage in many pathological conditions. The involvement of μ-calpain in neurological disorders such as, stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 6-Pyridone 2-carboxamides derived from ketoamides were synthesized as conformationally constrained structures resembling the well known peptidic μ-calpain ...