8-Methoxyquinolines as PDE4 inhibitors

…, M Minnicozzi, JG Montana, J Oxford, JC Peake…

Index: Billah, Motasim; Buckley, George M; Cooper, Nicola; Dyke, Hazel J; Egan, Robert; Ganguly, Ashit; Gowers, Lewis; Haughan, Alan F; Kendall, Hannah J; Lowe, Christopher; Minnicozzi, Michael; Montana, John G; Oxford, Janet; Peake, Joanna C; Picken, C Louise; Piwinski, John J; Naylor, Robert; Sabin, Verity; Shih, Neng-Yang; Warneck, Julie B H Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 12 p. 1617 - 1619

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Citation Number: 31

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4). ... The synthesis and pharmacological profile of a novel series of 2- ...