A mild and efficient new synthesis of aryl sulfones from boronic acids and sulfinic acid salts

C Beaulieu, D Guay, Z Wang, DA Evans

Index: Beaulieu, Christian; Guay, Daniel; Wang, Zhaoyin; Evans, David A. Tetrahedron Letters, 2004 , vol. 45, # 16 p. 3233 - 3236

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Citation Number: 44

Abstract

Sulfones are an important class of functional group in organic chemistry and medicinal chemistry as well. Aryl sulfones are widely used in medicinal chemistry and found on several drugs, including the recently developed selective COX-2 inhibitor Vioxx. 1 Many methodologies exist for the preparation of aryl sulfones. Among these methods figure the oxidation of corresponding sulfides, 2 the reaction of organolithium or Grignard reagents with sulfonate esters 3 and the sulfonylation of ...