A new synthesis of temozolomide
MJ Wanner, GJ Koomen
Index: Wanner, Martin J.; Koomen, Gerrit-Jan Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 16 p. 1877 - 1880
Full Text: HTML
Citation Number: 9
Abstract
An efficient condensation reaction between nitrosoimidazoles and phenyl methylcarbazate forms the basis of a new synthetic route to phenyloxycarbonyl substituted triazenylimidazoles. Exposure of these triazenes to diffuse daylight is sufficient to induce (E) to (Z)-isomerization of the triazene–NN–bond, resulting in spontaneous formation of temozolomide in high yield.
Related Articles:
Antitumor imidazotetrazines. 35. New synthetic routes to the antitumor drug temozolomide
[Wang, Yongfeng; Stevens, Malcolm F. G.; Chan, Tze-Ming; DiBenedetto, Donald; Ding, Zhe-Xing; Gala, Dinesh; Hou, Donald; Kugelman, Max; Leong, William; Kuo, Shen-Chun; Mas, Janet L.; Schumacher, Doris P.; Shutts, Bruce P.; Smith, Lyman; Zhan, Zheng-Yun J.; Thomson, William T. Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7288 - 7294]