An expedient, flexible and convergent access to selectively protected 1, 5-dicarbonyl compounds. Applications to the synthesis of 2, 6-disubstituted pyridines and …

J Boivin, F Carpentier, R Jrad

Index: Boivin, Jean; Carpentier, Floriane; Jrad, Rafik Synthesis, 2006 , # 10 p. 1664 - 1672

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Citation Number: 5

Abstract

Abstract Intermolecular addition of 2-oxoalkyl radicals generated from the corresponding S- alkyl-O-ethyl dithiocarbonates on vinyl ketals afforded selectively protected 1, 5-dicarbonyl compounds in good yields. These key-intermediates can be converted into a plethora of useful substances. Transformations to pyridines and thiopyridines were given as examples.