One carbon homologation of halides to benzyl ethers
DF Taber, CM Paquette, PG Reddy
Index: Taber, Douglass F.; Paquette, Craig M.; Reddy, P. Ganapati Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2462 - 2463
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Citation Number: 4
Abstract
Often in organic synthesis, removing unwanted steps in a synthetic route is convenient from both a time and material standpoint. Adding a step for protection of an alcohol after homologation can be circumvented by the approach presented here. This reduces both the time and the solvent costs needed to purify products, minimizing waste. ... As the starting point for a total synthesis, we needed the benzyl ether 2a. Although a multi-step preparation had been ...
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