Syntheses of a flobufen metabolite and dapoxetine based on enantioselective allylation of aromatic aldehydes

…, D Nečas, I Valterová, M Kotora

Index: Hessler, Filip; Korotvicka, Ales; Necas, David; Valterova, Irena; Kotora, Martin European Journal of Organic Chemistry, 2014 , vol. 2014, # 12 p. 2543 - 2548

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Citation Number: 4

Abstract

Abstract The enantioselective allylation of an aromatic aldehyde to give a chiral homoallylic alcohol was employed as the key step in the syntheses of a flobufen metabolite and dapoxetine. In the former case, the homoallylic alcohol moiety (99% ee) was converted into a five-membered lactone ring with good preservation of the optical purity, and the target compound, a flobufen metabolite, was obtained in 95% ee. In the latter case, the ...