Organic Letters 2011-10-07

Expedient Route to the functionalized calyciphylline A-type skeleton via a Michael addition-RCM strategy.

Filippo Sladojevich, Iacovos N Michaelides, Darses Benjamin, John W Ward, Darren J Dixon

Index: Org. Lett. 13(19) , 5132-5, (2011)

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Abstract

An efficient, robust, and scalable strategy to access the functionalized core of calyciphylline A-type alkaloids has been developed starting from commercially available 3-methylanisole. Key features of this approach are an intramolecular Michael addition/allylation sequence and a ring-closing metathesis step.© 2011 American Chemical Society