Indian Journal of Experimental Biology 2002-08-01

Solid state cultivation of Curvularia lunata for transformation of rifamycin B to S.

A A Rasalkar, B K Salunke, R Z Sayyed, A B Chaudhari, S B Chincholkar

Index: Indian J. Exp. Biol. 40(8) , 930-3, (2002)

Full Text: HTML

Abstract

Biotransformation of rifamycin B to rifamycin S using two strains of C. lunata namely NCIM 716 and NMU grown on various solid substrates viz., grass, paper, jowar/wheat straw, bran and bagasse was studied. Almost complete biotransformation efficiency of rifamycin B at 0. 06 mM concentration was observed within 24 hr. Among these two strains, C. lunata NMU showed 90% of biotransformation and higher rate of cellulose utilization on solid substrates vis-à-vis reference strain. Cellulase activity of both strains was also studied for exoglucanase, endoglucanase and beta-glucosidase. Column bioreactor studies with bagasse revealed further improvement in biotransformation efficiency of C. lunata NMU.

Related Compounds

Related Articles:

Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells.

1999-01-01

[Life Sci. 64(9) , 763-74, (1999)]

Phase shifts in the stoichiometry of rifamycin B fermentation and correlation with the trends in the parameters measured online.

2006-12-15

[J. Biotechnol. 127(1) , 115-28, (2006)]

Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis.

2005-08-17

[J. Am. Chem. Soc. 127(32) , 11202-3, (2005)]

Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699.

2011-10-01

[J. Bacteriol. 193(19) , 5562-3, (2011)]

Overproduction of rifamycin B by Amycolatopsis mediterranei and its relationship with the toxic effect of barbital on growth.

1998-01-01

[J. Antibiot. 51(1) , 58-63, (1998)]

More Articles...