Structural modification of sanguinarine and chelerythrine and their in vitro acaricidal activity against Psoroptes cuniculi

F Miao, XJ Yang, YN Ma, F Zheng, XP Song…

Index: Miao, Fang; Yang, Xin-Juan; Ma, Yan-Ni; Zheng, Feng; Song, Xiao-Ping; Zhou, Le Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1508 - 1513

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Citation Number: 19

Abstract

Sanguinarine (1) and chelerythrine (2) are two quaternary benzo [c] phenanthridine alkaloids (QBAs). Eighteen derivatives of 1 and 2 were synthesized by modification of C= N+ bond and evaluated for their in vitro acaricidal activity against Psoroptes cuniculi, a mange mite. A new method was developed to prepare 6-alkoxy dihydro derivatives of 1 and 2 (1a– e, 2a–e). Among all the compounds, only 6-alkoxy dihydrosanguinarines (1a–e) showed ...