Synthesis, biological evaluation and molecular docking studies of 1, 3, 4-oxadiazole derivatives as potential immunosuppressive agents

ZM Zhang, XW Zhang, ZZ Zhao, R Yan, R Xu…

Index: Zhang, Zhi-Ming; Zhang, Xue-Wei; Zhao, Zong-Zheng; Yan, Ru; Xu, Rui; Gong, Hai-Bin; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 10 p. 3359 - 3367

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Citation Number: 11

Abstract

A series of 1, 3, 4-oxadiazole derivatives derived from 4-methoxysalicylic acid or 4- methylsalicylic acid (6a–6z) have been first synthesized for their potential immunosuppressive activity. Among them, compound 6z displayed the most potent biological activity against lymph node cells (inhibition= 38.76% for lymph node cells and IC50= 0.31 μM for PI3Kγ). The preliminary mechanism of compound 6z inhibition effects ...