Total synthesis of (-)-incrustoporin.
Q Yu, J F Liu, Y L Wu
Index: J. Asian Nat. Prod. Res. 1(3) , 183-8, (1999)
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Abstract
(-)-Incrustoporin (1) has been synthesized using aldol condensation of ethyl p-tolyl-acetate (2) and (2R)-benzoyloxy-butanal (3), followed by acid-catalyzed deprotection of the benzoyl group, lactone ring-closure, and elimination of the beta-OH in a one-pot manner. The aldehyde 3 was prepared from the commercially available D-mannitol by a two-directional strategy.
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